SPIRT: A Fault-Tolerant and Reliable Peer-to-Peer Serverless ML Training Architecture

The advent of serverless computing has ushered in notable advancements in distributed machine learning, particularly within parameter server-based architectures. Yet, the integration of serverless features within peer-to-peer (P2P) distributed networks remains largely uncharted. In this paper, we introduce SPIRT, a fault-tolerant, reliable, and secure serverless P2P ML training architecture. designed to bridge this existing gap. Capitalizing on the inherent robustness and reliability innate to P2P systems, SPIRT employs RedisAI for in-database operations, leading to an 82\% reduction in the time required for model updates and gradient averaging across a variety of models and batch sizes. This architecture showcases resilience against peer failures and adeptly manages the integration of new peers, thereby highlighting its fault-tolerant characteristics and scalability. Furthermore, SPIRT ensures secure communication between peers, enhancing the reliability of distributed machine learning tasks. Even in the face of Byzantine attacks, the system's robust aggregation algorithms maintain high levels of accuracy. These findings illuminate the promising potential of serverless architectures in P2P distributed machine learning, offering a significant stride towards the development of more efficient, scalable, and resilient applications

In vitro and in vivo anti-melanoma effects of Daphne gnidium aqueous extract via activation of the immune system

The purpose of this study was to assess the antitumor and immunomodulatory effects of the aqueous extract from Daphne gnidium in mice-bearing melanoma tumor. Balb/C mice were subcutaneously implanted with B16-F10 cells and treated intraperitoneally with the aqueous extract at 200 mg/Kg b.w for 21 days. After euthanization on day 22, the tumors were weighed; lymphocyte proliferation, cytotoxic T lymphocyte (CTL), and natural killer (NK) cell activities were evaluated using the MTT assay. Macrophage phagocytosis was studied by measuring the lysosomal activity. In addition to its potential to inhibit the growth of the transplantable tumor, the aqueous extract remarkably induced splenocyte proliferation and both NK and CTL activities in tumor-bearing mice. The aqueous extract was also seen to have promoted lysosomal activity of host macrophages